Cisplatin mitophagy

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August undefined, 2024

WebDec 1, 2024 · The “oncoPredict” package showed that the high risk mitophagy group had a lower sensitive score than low risk mitophagy group in a series of drugs (Table 1). To be noted, compared to low risk mitophagy group, the high risk mitophagy was more sensitive to cisplatin and gemcitabine, which were often used in the treatment of LUAD. 3.5. WebMar 15, 2024 · It has been found that PNS is able to alleviate cisplatin-induced nephrotoxicity by inducing BNIP3-mediated mitophagy via hypoxia-inducible factor-1α (HIF-1α). PNS treatment restores renal function via attenuating the accumulation of injury mitochondria and cell apoptosis in TECs ( Liang et al., 2024 ; Li et al., 2024c ).

Mitophagy Impairment Aggravates Cisplatin-Induced Ototoxicity

WebDec 31, 2024 · Since metformin is used as adjuvant drug to increase the efficacy of cisplatin-based neoadjuvant chemotherapy, we co-treated tumour cells with micromolar doses of metformin in the presence of cisplatin observing a marked reduction of MAP1LC3B-II and an increase of caspase 3 cleavage. ... Mitophagy, as assessed by … WebAug 7, 2024 · Mitophagy, a term first proposed by Lemasters (2005), refers to a process by which mitochondria are selectively degraded by autophagy ( Palikaras et al., 2024 ), which has emerged as an important mechanism of mitochondrial quality and quantity control ( Pickles et al., 2024 ). immigration lawyer quad cities

Frontiers Farrerol Ameliorated Cisplatin-Induced Chronic Kidney ...

WebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between … WebThe role of autophagy/mitophagy was investigated by transient transfection of siATG14, GFP-LC3, tF-LC3, mKeima-Red-Mito7 and Western blot analysis of autophagic and mitochondrial proteins. Results: In vitro and OSCC tissue double labelling confirmed that CD44+cells co-expresses ABCB1 and ADAM17. WebMay 20, 2024 · Cisplatin ototoxicity is associated with cochlear cell oxidative stress and mitochondrial damage. However, mitophagy is vital for maintaining mitochondrial quality and cellular metabolism. Accordingly, we investigated the role of mitophagy in regulating cisplatin-induced ototoxicity using the auditory cell line HEI-OC1. immigration lawyer poznan

Berberine alleviates cisplatin-induced acute kidney injury by ...

Stork: Mitophagy alleviates cisplatin-induced renal tubular …

WebScience topic Sirtuin 1. A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in ... WebApr 22, 2024 · Cisplatin (CDDP) is commonly used to treat a multitude of tumors including sarcomas, ovarian and cervical cancers. immigration lawyer prince edward islandWebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. list of the greatest empires in history

"WebNov 5, 2024 · While cisplatin induced a severe mitophagy defect, mitolysosomes represented by the mCherry signal were markedly higher in Casp9 HZ renal tubule cells exposed to cisplatin (Fig. 6A). Cisplatin induced marked mitochondrial depolarization in kidney tubule cells, which was ameliorated in Casp9 HZ renal tubule cells ( Fig. 6B ). " - Cisplatin mitophagy

Cisplatin mitophagy

Suppression of DRP1‑mediated mitophagy increases the

WebOct 12, 2024 · Gastric cancer (GC) is one of the most common tumors worldwide, and cisplatin is a standard chemotherapeutic reagent for GC treatment. However, chemoresistance is an inherent challenge which limits its application and effectiveness in clinic. This study aims to investigate the mechanism of metformin-induced cisplatin … WebOct 7, 2024 · Chaetomugilin J Inhibits Mitophagy Induced by Cisplatin. Mitophagy is a type of autophagy that eliminates redundant or damaged mitochondria. 26 It plays an important role in mitochondrial function. The expression of pink1 and parkin, which are mitophagy-related proteins, were detected to reflect mitophagy.

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WebMar 28, 2024 · Although mitophagy is considered of particular importance in protecting against AKI, little is known of the precise role of mitophagy and its molecular mechanisms during cisplatin-induced nephrotoxicity. Also, evidence that activation of mitophagy improved mitochondrial function is lacking. WebMar 7, 2024 · Recently, some authors believed that miR34a and mitophagy played a role in age-related and drug-induced hearing loss. Our study aimed to explore the involvement of miR-34a/DRP-1-mediated mitophagy in cisplatin-induced ototoxicity. Methods: In this study, C57BL/6 mice and HEI-OC1 cells were treated with cisplatin.

WebA total of 407 drugs are known to interact with cisplatin : 77 major drug interactions (291 brand and generic names) 311 moderate drug interactions (1044 brand and generic … WebBackground and Objectives: Combination therapy improves the effect of chemotherapy on tumor cells. Magnolol, used in treating gastrointestinal disorders, has been shown to have anti-cancer properties. We investigated the synergistic effect of cisplatin and magnolol on the viability and maintenance of MKN-45 gastric cancer cells. Materials and Methods: …

WebBackground: To study the protective effect of berberine (BBR) on cisplatin-induced acute kidney injury (AKI) and its effect on mitophagy. Methods: (I) Male C57BL/6 mice aged 6-8 weeks were randomly divided into control group (saline), cisplatin group (cisplatin), and cisplatin + BBR (5, 10 mg/kg) groups. WebJun 1, 2024 · Modulation of cisplatin-induced apoptosis by stimulation or suppression of mitophagy. (A) Cisplatin stimulates apoptosis in HCT116 and SK-N-BE(2) assessed by …

WebFeb 13, 2024 · Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. Ferropt …

WebApr 22, 2024 · Specifically, levels of the mitophagy receptor BNIP3 are higher both in resistant cells and in ovarian cancer patient samples resistant to platinum-based treatments. Genetic BNIP3 silencing or pharmacological inhibition of autophagosome formation re-sensitizes these cells to CDDP. immigration lawyer princeton njWebJul 5, 2024 · Mitophagy is a cytoprotective process in the adaptation to chemotherapy drug treatment. Therefore, targeting mitochondria is regarded as a promising anticancer … immigration lawyer riga price listWebJan 16, 2024 · We examined the sensitivity of 20 human cancer cell lines to X-rays, carbon ions, or cisplatin in a clonogenic survival assay (Figs 1,2).Details of the parameters … immigration lawyer robert westWebNov 26, 2024 · Cisplatin is one of the commonly used anticancer drugs in clinic chemotherapy, but drug resistance is a major therapeutic obstacle for successful treatment. While ginkgolic C17:1 alone induced autophagy and apoptosis in the human hepatoblastoma cells HepG2, it was found to paradoxically inhibit cisplatin-induced … list of the greek godsWebCisplatin exerts its therapeutic efficacy by interfering with DNA replication but also by interacting with other nucleophilic species within cells, including side chains of … immigration lawyer saint john nbWebCisplatin exerts its therapeutic efficacy by interfering with DNA replication but also by interacting with other nucleophilic species within cells, including side chains of mitochondrial proteins and nucleotides. Mitochondria are key signaling hubs that fundamentally contribute to cancer development and progression. immigration lawyer reviews paddingtonWebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between mitophagy and the protective effect of the Nrf2 activator farrerol on cisplatin-induced CKD by using C57BL/6 wild-type and Nrf2 knockout mice. immigration lawyer richland county