WebDethiobiotin synthetase from Mycobacterium tuberculosis (MtDTBS) is a promising antituberculosis drug target. Small-molecule inhibitors that target MtDTBS provide a route towards new therapeutics for the treatment of antibiotic-resistant tuberculosis. Adenosine diphosphate (ADP) is an inhibitor of MtDTBS; however, structural studies into its ... WebSpecifically, DTBS allows for the ATP-dependent formation of dethiobiotin from 7,8-diaminopelargonic acid (DAPA) and CO 2 by catalyzing a ureido ring formation(4). The …
[61] Dethiobiotin synthetase - ScienceDirect
WebSep 5, 1995 · Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF 3 -diaminopelargonic acid and enzyme-MgADP-dethiobiotin … WebApr 16, 2010 · Dethiobiotin synthetase (DTBS) is involved in the biosynthesis of biotin in bacteria, fungi, and plants. As humans lack this pathway, DTBS is a promising antimicrobial drug target. We determined structures of DTBS from Helicobacter pylori (hpDTBS) bound with cofactors and a substrate analog, and described its unique characteristics relative to ... great lumley junior school
Dethiobiotin synthetase: the carbonylation of 7,8 ... - PubMed
WebSep 5, 1995 · Dethiobiotin synthetase (DTBS) catalyzes the penultimate step in biotin biosynthesis, the formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (7,8-diaminopelargonic acid, DAPA), CO2, and ATP. Solutions of DAPA at neutral pH readily formed a mixture of the N7- and N8-carbamates in the … WebProtein target information for Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial (thale cress). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. WebNov 1, 2000 · Sequence analysis of this fragment revealed that it is closely related to a family of ATP-dependent enzymes that also includes dethiobiotin synthetase and the synthetase domains of two amidotransferases involved in cobalamin biosynthesis, cobyrinic acid a,c-diamide synthase (CobB) and cobyric acid synthase (CobQ). flood defender dishwasher kit