Phosphatidic acid phosphatase type 2
WebMagnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P ( PubMed: 9705349, … WebThis protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP …
Phosphatidic acid phosphatase type 2
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WebMar 11, 2024 · Lipin/Pah phosphatidic acid phosphatases (PAPs) generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Inactivating mutations cause rhabdomyolysis, autoinflammatory disease, and aberrant fat storage. Disease-mutations cluster within the conserved N-Lip and C-Lip regions that are separated by 500-residues in … WebJan 5, 2007 · Brain, liver, kidney, heart, and skeletal muscle from fatty liver dystrophy (fld/fld) mice, which do not express lipin 1 (lipin), contained much less Mg 2+-dependent phosphatidic acid phosphatase (PAP) activity than tissues from wild type mice.Lipin harboring the fld 2j (Gly 84 → Arg) mutation exhibited relatively little PAP activity. These …
WebPhosphatidic acid phosphatase (PAP) enzyme catalyzes the dephosphorylation of phosphatidic acid (PA) to yield diacylglycerol (DAG), a key precursor for TAG biosynthesis. … WebOct 24, 2024 · The phosphatase activity against phosphatidic acid was independent of Mg (2+), insensitive to N-ethylmaleimide treatment, and inhibited by propranolol and …
WebFurthermore, ABA-induced production of nitric oxide (NO) was impaired in pldalpha1 guard cells. Disruption of PA binding to ABI1 protein phosphatase 2C did not affect ABA-induced production of ROS or NO, but the PA-ABI1 interaction was required for stomatal closure induced by ABA, H(2)O(2), or NO. WebPhosphatidylethanolamine (PE) Biological Function PE is the second most abundant phospholipid in mammalian membranes, contributing 20-30% of total phospholipid content. It is found in greater abundance in the inner leaflet of the plasma membrane, with approximately 20% of plasma membrane PE found on the outer leaflet.
WebAnti-Phosphatidic acid phosphatase type 2B antibody (ab221918) Datasheet. SDS. Submit a review Submit a question. $645 Product size. 100 µl. Add to basket. The lead time on this item is currently 1-2 weeks.
WebIt is a type 2 activity PAP, which localizes to the plasma membrane, and is one of four known LPP isoforms. As an integral membrane protein, LPP3 contains six hydrophobic transmembrane domains and a hydrophilic catalytic site … smernice up pefWebApr 1, 1999 · The type 2 phosphatidic acid phosphatase enzyme family. (A) The type 2 phosphatidic acid phosphatases (PAP-2) and their homologs are presented with the … smernice nis2WebROLES OF PA PHOSPHATASE IN LIPID METABOLISM AND ITS IMPORTANCE TO CELL PHYSIOLOGY Phosphatidic acid (PA) phosphatase,2 the enzyme that catalyzes the Mg2+ … smernice tpo